Non-canonical effector functions of the T-memory-like T-PLL cell are shaped by cooperative TCL1A and TCR signaling

T-cell prolymphocytic leukemia (T-PLL) is a poor-prognostic neoplasm. Differentiation stage and immune-effector functions of the underlying tumor cell are insufficiently characterized. Constitutive activation of the T-cell-leukemia-1A (TCL1A) oncogene distinguishes the (pre)leukemic cell from regula...

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Published in:	Blood
Main Authors:	Oberbeck, Sebastian, Schrader, Alexandra, Warner, Kathrin, Jungherz, Dennis, Crispatzu, Giuliano, von Jan, Jana, Chmielewski, Markus, Ianevski, Aleksandr, Diebner, Hans H, Mayer, Petra, Kondo Ados, Aichatou, Wahnschaffe, Linus, Braun, Till, Müller, Tony A, Wagle, Prerana, Bouska, Alyssa, Neumann, Tom, Pützer, Sabine, Varghese, Lesley, Pflug, Natali, Thelen, Martin, Makalowski, Jennifer, Riet, Nicole, Göx, Hedwig Julia Maria, Rappl, Gunter, Altmüller, Janine, Kotrova, Michaela, Persigehl, Thorsten, Hopfinger, Georg, Hansmann, Martin L, Schlößer, Hans, Stilgenbauer, Stephan, Dürig, Jan, Mougiakakos, Dimitrios, von Bergwelt-Baildon, Michael, Roeder, Ingo, Hartmann, Sylvia, Hallek, Michael, Moriggl, Richard H, Brüggemann, Monika, Aittokallio, Tero, Iqbal, Javeed, Newrzela, Sebastian, Abken, Hinrich, Herling, Marco
Format:	Journal Article
Language:	English
Published:	United States 21-09-2020
Online Access:	Get full text
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