Randomized Clinical Trial investigating Self-Assembling Peptide P 11 -4 for Treatment of Early Occlusal Caries

• Published in: Scientific reports Vol. 10; no. 1; p. 4195
• Main Authors: Doberdoli, Dafina, Bommer, Claudine, Begzati, Agim, Haliti, Fehim, Heinzel-Gutenbrunner, Monika, Juric, Hrvoje
• Format: Journal Article
• Language: English
• Published: England 06-03-2020
• Subjects: Adolescent; Child; Dental Caries - drug therapy; Female; Fluorides - therapeutic use; Glycosyltransferases - therapeutic use; Humans; Male; Surveys and Questionnaires
• ISSN: 2045-2322

Non-invasive caries treatment is a major focus in modern dentistry. The present study was designed to evaluate the effectiveness of monomeric self-assembling peptide P
-4 (SAP P
-4) in combination with fluoride varnish or polymeric self-assembling peptide matrix (SAPM) in treatment of non-cavitated occlusal caries. Ninety children and adolescents were included in this randomized, gold-standard-controlled clinical trial. Test Group 1 received SAP P
-4 and twice fluoride varnish at baseline and Day 180, Test Group 2 received SAP P
-4 on baseline and twice weekly SAPM (home-application), and Control Group received fluoride varnish on baseline and Day 180. Caries progression was measured by laser fluorescence, Nyvad Caries Activity, ICDAS-II-codes, and investigator assessments. Laser fluorescence changes demonstrated superior results for Test Group 1 and 2, as values decreased compared to an increase for the Control Group (p < 0.0005). ICDAS-II codes at Day 360 showed partial regression for Test Group 1 (6.7%) and Test Group 2 (20.0%) and partial progression for Control Group (23.3%) (p < 0.01). Nyvad Caries Activity yielded superior caries inactivation for Test Groups, compared to Control Group (p = 0.002). This trial showed that SAP P
-4, applied either in combination with fluoride varnish or twice weekly SAPM, was a superior treatment for early caries compared to fluoride varnish alone.