CB 2 receptor activation causes an ERK1/2-dependent inflammatory response in human RPE cells

A chronic low-level inflammation contributes to the pathogenesis of age-related macular degeneration (AMD), the most common cause of blindness in the elderly in Western countries. The loss of central vision results from attenuated maintenance of photoreceptors due to the degeneration of retinal pigm...

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Bibliographic Details

Published in:	Scientific reports Vol. 7; no. 1; p. 16169
Main Authors:	Hytti, M, Andjelic, S, Josifovska, N, Piippo, N, Korhonen, E, Hawlina, M, Kaarniranta, K, Nevalainen, T J, Petrovski, G, Parkkari, T, Kauppinen, A
Format:	Journal Article
Language:	English
Published:	England 23-11-2017
Subjects:	Cannabinoids - pharmacology Cell Death - drug effects Cell Line Humans Inflammation - metabolism Macular Degeneration - metabolism Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Oxidative Stress - drug effects Receptor, Cannabinoid, CB2 - agonists Receptor, Cannabinoid, CB2 - metabolism Retinal Pigment Epithelium - metabolism Signal Transduction - drug effects
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