Factors related to residual renal function loss in patients in peritoneal dialysis

• Published in: Revista médica (Mexico : 1983) Vol. 53; no. 5; p. 578
• Main Authors: Munguía-Miranda, Catarina, Ventura-García, María de Jesús, Ávila-Díaz, Marcela, Orihuela-Rodríguez, Oscar, Paniagua-Sierra, José Ramón
• Format: Journal Article
• Language: Spanish
• Published: Mexico 01-09-2015
• Subjects: Adult; Aged; Diabetes Mellitus, Type 2 - complications; Diabetic Nephropathies - etiology; Diabetic Nephropathies - physiopathology; Diabetic Nephropathies - therapy; Female; Humans; Kidney - physiopathology; Kidney Failure, Chronic - etiology; Kidney Failure, Chronic - physiopathology; Kidney Failure, Chronic - therapy; Kidney Function Tests; Male; Middle Aged; Peritoneal Dialysis, Continuous Ambulatory; Renal insufficiency; Kidney diseases; Peritoneal dialysis
• ISSN: 0443-5117

Residual renal function (RRF) contributes to the quality of life of patients on dialysis. The preservation of RRF is associated with higher patient survival in peritoneal dialysis (PD), and is now accepted that RRF and peritoneal clearance are not of equal value in patient survival. The aim of this study is to know the factors related to RRF loss in prevalent patients in continuous ambulatory peritoneal dialysis (CAPD).
This is an analysis of secondary outcomes. Forty-three adult patients with type 2 diabetes were included. They had RRF preserved. Clinical and laboratory assessments were done in each visit during a year.
The male gender (p = 0.042), systolic (p = 0.009) and diastolic (p = 0.006) blood pressure (BP), hemoglobin (p = 0.008), peritoneal creatinine clearance (p = 0.014), peritoneal ultrafiltration (p = 0.017) and levels of tumor necrosis factor-alpha (TNF-alpha) in plasma (p = 0.022) and dialysate (p = 0.008) were related with RRF loss.
It is important to understand the factors associated with RRF loss in our patients to prevent the gradual loss and its implications on the mortality and quality of life.