Reversible immunosuppression, liver and kidney markers, calcium and phosphorus in the healthy rabbit

• Published in: Le Mali medical Vol. 26; no. 2; p. 31
• Main Authors: Yapi Houphouet, Félix, Yapo, Adou, Bidié Alain, Dit Phillipe, Ahiboh, Hugues, Yayo, Eric, Hauhouot-Attounbre, Marie-Laure, Nguessan-Edjeme, Angèle, Monnet, Dagui, Djaman, Allico Joseph
• Format: Journal Article
• Language: French
• Published: Mali 2011
• Subjects: Alanine Transaminase - blood; Animals; Aspartate Aminotransferases - blood; Biomarkers - blood; Blood Proteins; Calcium - blood; Creatinine - blood; Dose-Response Relationship, Drug; Glucocorticoids - administration & dosage; Immunosuppression; Methylprednisolone - administration & dosage; Phosphorus - blood; Rabbits; Urea - blood
• ISSN: 1993-0836

The aim of this study was to determine one or several doses of Methylprednisolone ( MP) who leads a long time of immunosuppression without disrupting phosphor and calcium, liver and kidney markers at the healthy rabbit.
This study was made to fifteen rabbit. Five (5) batches were constituted according to Nacl and Methylpredmisolone administered dose by body weight. Control batch ( Nacl 0,9%); batch I (2,5mg / kg MP); batch II ( 5mg / kg MP); batch III ( 10mg / kg MP) and batch IV ( 15 mg / kg MP). Biochemical parameters were measured by chemical and enzymatic methods.
The results of this study showed an immunosuppression during seven days with 10 and 15 mg / kg of MP doses (P < 0.05). The biochemical disturbances were only observed with 15 mg / kg dose where calcium was lowered to day 15 and TGO increased to day 3 according to day 0 (P < 0.05).
This study showed that the doses which lead a long time of immunosuppression ( 7 days) are 10 and 15 mg / kg of MP, then the dose which does not disrupt the biochemical parameters is 10 mg / kg of MP.