Effect of small doses of diphtheria exotoxin on cell cultures

High diphtheria exotoxin concentrations induced irreversible injuries to all the cultures under study (L, HeLa, spcv pzM). However, its final titres in the mentioned cells differed. HeLa and pzM cells, being highly sensitive, can be recommended for titration of dipheria exotoxin, instead of the expe...

Full description

Saved in:

Bibliographic Details
Published in:	Žurnal mikrobiologii, ėpidemiologii i immunobiologii no. 1; p. 79
Main Authors:	Sovetova, G P, Kravchenko, A T, Dzagurov, S G
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-01-1979
Subjects:	Animals Callitrichinae Diphtheria Toxin - administration & dosage Diphtheria Toxin - analysis Diphtheria Toxin - toxicity HeLa Cells Kidney - embryology L Cells (Cell Line) Mitosis Swine Vesicular stomatitis Indiana virus - pathogenicity
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	High diphtheria exotoxin concentrations induced irreversible injuries to all the cultures under study (L, HeLa, spcv pzM). However, its final titres in the mentioned cells differed. HeLa and pzM cells, being highly sensitive, can be recommended for titration of dipheria exotoxin, instead of the expensive guinea pig tests. Low (subtoxic) doses produced cytoproliferative action and caused changes of the cell properties.
ISSN:	0372-9311