Moraprenylphosphates suppress reproduction of Taylor murine encephalomyelitis virus and accumulation of VP3 viral protein in susceptible cell cultures BHK-21 and P388D1

Influence of moraprenylphosphates (phosphorylated polyprenol of plant origin) upon the accumulation of Taylor murine encephalomyelitis virus VP3 protein in the susceptible cell cultures was studied. It has been shown that moraprenylphosphates inhibited the accumulation of VP3 at early stages of infe...

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Bibliographic Details
Published in:	Žurnal mikrobiologii, ėpidemiologii i immunobiologii no. 3; p. 26
Main Authors:	Kozhevnikova, T N, Viktorova, E G, Kozlov, V G, Narovlianskiĭ, A N, Sanin, A V, Pronin, A V, Ozherelkov, S V
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-05-2007
Subjects:	Animals Antiviral Agents - pharmacology Capsid Proteins - biosynthesis Capsid Proteins - drug effects Cardiovirus Infections - virology Cell Line - drug effects Cell Line - virology Cricetinae Mice Polyisoprenyl Phosphates - pharmacology Theilovirus - drug effects Theilovirus - pathogenicity Theilovirus - physiology Virulence - drug effects
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Summary:	Influence of moraprenylphosphates (phosphorylated polyprenol of plant origin) upon the accumulation of Taylor murine encephalomyelitis virus VP3 protein in the susceptible cell cultures was studied. It has been shown that moraprenylphosphates inhibited the accumulation of VP3 at early stages of infectious process. Moraprenylphosphates were found to decrease infectivity of the virus as well as virus-induced cellular apoptosis. Mechanisms of immunomodulating and antiviral activity of moraprenylphosphates and prospects of their use as antiviral drugs have been discussed.
ISSN:	0372-9311