Clinical and immunological characteristics of rubella in western Siberia

• Published in: Žurnal mikrobiologii, ėpidemiologii i immunobiologii no. 2; p. 44
• Main Authors: Malkova, E M, Petrova, I D, Smerdova, M A, Obert, A S, Pomogaeva, A P, Minakova, Iu V, Iur'ev, S Iu, Krasnov, A V, Khokhlova, Z A, Golubina, E A, Zinov'eva, L I, Krasman, O M, Ustinova, E N, Tiunnikov, G I, Iashina, L N, Netesov, S V, Petrov, V S
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01-03-2007
• Subjects: Adolescent; Adult; Antibodies, Viral - blood; Antibodies, Viral - immunology; Antibody Affinity; Carrier State - diagnosis; Carrier State - immunology; Child; Child, Preschool; Disease Progression; Enzyme-Linked Immunosorbent Assay; Female; Humans; Infant; Male; Reverse Transcriptase Polymerase Chain Reaction; RNA, Viral - analysis; Rubella - diagnosis; Rubella - immunology; Rubella - virology; Rubella virus - genetics; Rubella virus - immunology; Rubella virus - isolation & purification; Siberia; Siberia
• ISSN: 0372-9311

Evaluations of immune system of 155 patients with rubella and 90 contacts with patients were examined. Detection of viral genetic material in blood, urine, and nasopharyngeal swabs has been performed using RT-PCR method. Clinical diagnosis has been confirmed by RT-PCR in 114 (73.5%) patients. Changes of laboratory tests for rubella without clinical signs of the infection were observed in 20% of contacts. Complex ELISA- and PCR-assisted examination of patients can help to determine the stage of disease and characteristics of immune response. For differential diagnostic of rubella and other infectious diseases with exanthema it is rational to perform complex examination of patients using immunologic and molecular biologic methods.