Biological activity of the components of F1-antigen of Yersinia pestis

• Published in: Žurnal mikrobiologii, ėpidemiologii i immunobiologii no. 3; p. 76
• Main Authors: Kosse, L V, Lebedeva, S A, Cherniavskaia, A S, Nekliaev, V N, Markina, O V, Morozova, I V, Eremenko, N S, Sal'nikova, O I
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01-05-2006
• Subjects: Adhesins, Bacterial - immunology; Animals; Antibodies, Bacterial - immunology; Bacterial Capsules - immunology; Bacterial Proteins - immunology; Cell Line; Cytotoxicity Tests, Immunologic; Erythrocytes - immunology; Fimbriae Proteins - immunology; Guinea Pigs; Hemolysis - immunology; Humans; Injections, Intraperitoneal; Lymphocyte Activation; Macrophages, Peritoneal - immunology; Mice; Plague - prevention & control; Plague Vaccine - administration & dosage; Rabbits; Reagent Kits, Diagnostic; T-Lymphocytes - immunology; Vaccination; Yersinia pestis - immunology
• ISSN: 0372-9311

Components of the capsule antigen (Baker), described early as F17, F18, F43, Flp, which positively reacts with commercial poly- and monoclonal antifractions plague diagnosticums were studied. Differences and their impacts on vaccine bacteria survival within peritoneal macrophages, guinea pigs and protection of white mice after immunization and fast protection against plague were shown. Hemolytic, cytolytic and hemo- and cytoagglutinations activities of lipoprotein (Flp) and capacity of glycoproteins F17 and F43 for induction of hemo- and cytoagglutinations were detected. Similarity of properties of enumerated components and lectins and their role in infection development and immunogenesis are discussed.