The use of monolaurates for removing endotoxins from preparations of cell-free pertussis vaccine

The possibility of using monolaurates for removing endotoxin from acellular pertussis vaccines developed at the Laboratory of Immunomodulators, Mechnikov Research Institute for Vaccines and Sera (Moscow), has been studied. Monolaurates PEG-400 and PEG-600 obtained, respectively, from Fluka Chemie AG...

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Bibliographic Details
Published in:	Žurnal mikrobiologii, ėpidemiologii i immunobiologii no. 7-8; p. 37
Main Authors:	Perel'man, E V, Bulk, V F, Remova, T N, Bazhanova, I G, Ozeretskovskaia, M N, Zakharova, N S
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 1992
Subjects:	Animals Drug Evaluation, Preclinical Indicators and Reagents Laurates Methods Mice Pertussis Vaccine - immunology Pertussis Vaccine - isolation & purification Pertussis Vaccine - toxicity Polyethylene Glycols Virulence Factors, Bordetella - isolation & purification Virulence Factors, Bordetella - toxicity
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Summary:	The possibility of using monolaurates for removing endotoxin from acellular pertussis vaccines developed at the Laboratory of Immunomodulators, Mechnikov Research Institute for Vaccines and Sera (Moscow), has been studied. Monolaurates PEG-400 and PEG-600 obtained, respectively, from Fluka Chemie AG and Ferak GmbH (Germany) have been used. The use of monolaurate PEG-600 ensures the decrease of the toxicity of acellular pertussis vaccines by 2.34-6.3 times.
ISSN:	0372-9311