A new algorithm for the alignment of multiple protein structures using Monte Carlo optimization

We have developed a new algorithm for the alignment of multiple protein structures based on a Monte Carlo optimization technique. The algorithm uses pair-wise structural alignments as a starting point. Four different types of moves were designed to generate random changes in the alignment. A distanc...

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Bibliographic Details

Published in:	Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing p. 275
Main Authors:	Guda, C, Scheeff, E D, Bourne, P E, Shindyalov, I N
Format:	Journal Article
Language:	English
Published:	United States 2001
Subjects:	Algorithms Amino Acid Sequence Aspartic Acid Endopeptidases - chemistry Aspartic Acid Endopeptidases - genetics Databases, Factual Molecular Sequence Data Monte Carlo Method Protein Kinases - chemistry Protein Kinases - genetics Proteins - chemistry Proteins - genetics Sequence Alignment - statistics & numerical data Sequence Homology, Amino Acid
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