Parathyphoid B-antigen containing a complex of protective surface antigens

The authors obtained a complex antigen from paratyphoid B bacilli containing complete O-, K- and H-antigens. The preparation was nontoxic and was characterised by marked antigenic properties. In intravenous and oral administration it stimulated production of specific O-, K-, and H-antibodies in high...

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Bibliographic Details
Published in:	Žurnal mikrobiologii, ėpidemiologii i immunobiologii no. 11; p. 41
Main Authors:	Stepanova, L K, Sergeeva, N S, Belaia, Iu A
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-11-1978
Subjects:	Administration, Oral Animals Antibodies, Bacterial - analysis Antibodies, Bacterial - biosynthesis Antigens, Bacterial - analysis Immunization, Secondary Injections, Intravenous Injections, Subcutaneous Mice Paratyphoid Fever - prevention & control Rabbits Salmonella paratyphi B - immunology Typhoid-Paratyphoid Vaccines - administration & dosage Typhoid-Paratyphoid Vaccines - analysis Vaccination
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Summary:	The authors obtained a complex antigen from paratyphoid B bacilli containing complete O-, K- and H-antigens. The preparation was nontoxic and was characterised by marked antigenic properties. In intravenous and oral administration it stimulated production of specific O-, K-, and H-antibodies in high titres. Complex paratyphoid B antigen possessed a marked protective activity and provided intense immunity in subcutaneous and oral administration to experimental animals.
ISSN:	0372-9311