North- and South-Bicyclo[3.1.0]Hexene Nucleosides: The Effect of Ring Planarity on Anti-HIV Activity (ChemMedChem 8/2009)

The inside cover picture shows the locked north (blue) and south (red) bicyclo[3.1.0]hexane nucleosides in the normal pseudorotational cycle, and the corresponding shift to a smaller cycle (nmax=7 ) caused by the insertion of a double bond. The former nucleosides are inactive, while the flattening o...

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Bibliographic Details
Published in:	ChemMedChem Vol. 4; no. 8; p. 1210
Main Authors:	Russ, Pamela L, Gonzalez-Moa, Maria J, Vu, B Christie, Sigano, Dina M, Kelley, James A, Lai, Christopher C, Deschamps, Jeffrey R, Hughes, Stephen H, Marquez, Victor E
Format:	Journal Article
Language:	German
Published:	03-08-2009
Subjects:	Human immunodeficiency virus
Online Access:	Get full text
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Summary:	The inside cover picture shows the locked north (blue) and south (red) bicyclo[3.1.0]hexane nucleosides in the normal pseudorotational cycle, and the corresponding shift to a smaller cycle (nmax=7 ) caused by the insertion of a double bond. The former nucleosides are inactive, while the flattening of the embedded cyclopentene ring provides active compounds against HOS cells infected with HIV. For more details, see the Full Paper by V. E. Marquez et al. on p. 1354 ff.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 content type line 23 ObjectType-Feature-2
ISSN:	1860-7179
DOI:	10.1002/cmdc.200990036