Reactive Keratoacanthoma Following Treatment with 5-Fluorouracil

Reactive Keratoacanthoma Following Treatment with 5-Fluorouracil

Keratoacanthoma (KA) is an epidermal cell tumor with a central keratin plug known to be a variant of keratinocyte carcinoma (KC). KAs typically arise from ultraviolet (UV)-damaged skin and thus are particularly prevalent on extremities. KAs can also be a consequence of local skin trauma. 5-fluoroura...

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Bibliographic Details
Published in:The Journal of clinical and aesthetic dermatology Vol. 16; no. 12; pp. 55 - 56
Main Authors: Paradkar, Komal A, Plotner, Alisha N
Format: Report
Language:English
Published: 01-12-2023
Online Access:Get full text
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Summary:Keratoacanthoma (KA) is an epidermal cell tumor with a central keratin plug known to be a variant of keratinocyte carcinoma (KC). KAs typically arise from ultraviolet (UV)-damaged skin and thus are particularly prevalent on extremities. KAs can also be a consequence of local skin trauma. 5-fluorouracil (5-FU) is a topical therapy used to treat early KC, as well as actinic keratoses (AKs). In this paper, we describe the unique cases of two elderly female patients who were treated with 5-FU for AKs of the lower extremities but developed severe inflammatory reactions and reactive KAs to the topical therapy.
Bibliography:ObjectType-Case Study-2
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ObjectType-Report-1
ISSN:1941-2789