The odds and implications of coinheritance of hemophilia A and B

• Published in: Research and practice in thrombosis and haemostasis Vol. 4; no. 5; pp. 931 - 935
• Main Authors: Karch, Corinne, Masser-Frye, Diane, Limjoco, Jacqueline, Ryan, Sarah E, Fletcher, Shelley N, Corbett, Kevin D, Johnsen, Jill M, Thornburg, Courtney D
• Format: Report
• Language: English
• Published: 01-07-2020
• ISSN: 2475-0379
• DOI: 10.1002/rth2.12345

We report 2 patients with coinheritance of the X-linked bleeding disorders hemophilia A and hemophilia B. We describe the family pedigrees, clinical features, and genotyping. The case report addresses the key clinical questions of how to manage patients with both hemophilia A and B and how to counsel families regarding recurrence risk. The patients with coinherited hemophilia A and B require a combination of factor VIII and factor IX replacement to achieve hemostasis. We calculated the estimated genomic meiotic recombination frequency between F8 and F9 to be 38%. The findings in these cases are consistent with this calculation. These findings provide critical information for management of families with coinherited hemophilia A and B.