Ten-year incidence and risk factors of bone fractures in a cohort of treated HIV1-infected adults

Ten-year incidence and risk factors of bone fractures in a cohort of treated HIV1-infected adults

In the ANRS CO8 APROCO-COPILOTE cohort of patients treated with combination antiretroviral therapy since 1997-1999, the incidence density of bone fractures was 3.3 for 1000 patient-years [95% confidence interval (CI) = 2.0--4.6]. The rate was 2.9-fold (95% CI = 1.3-6.5) higher among patients with ex...

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Bibliographic Details
Published in:AIDS (London) Vol. 23; no. 8; p. 1021
Main Authors: Collin, F, Duval, X, Le Moing, V, Piroth, L, Kaied, F A, Massip, P, Villes, V, Chene, G, Raffi, F
Format: Journal Article
Language:English
Published: 15-05-2009
Subjects:
Hepatitis C virus
Human immunodeficiency virus
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Summary:In the ANRS CO8 APROCO-COPILOTE cohort of patients treated with combination antiretroviral therapy since 1997-1999, the incidence density of bone fractures was 3.3 for 1000 patient-years [95% confidence interval (CI) = 2.0--4.6]. The rate was 2.9-fold (95% CI = 1.3-6.5) higher among patients with excessive alcohol consumption and 3.6-fold (95% CI = 1.6-8.1) higher in those with hepatitis C virus (HCV) coinfection. Specific monitoring of HCV/HIV-coinfected patients and active promotion of alcohol cessation should be recommended for the prevention of bone fractures.
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ISSN:0269-9370
DOI:10.1097/QAD.0b013e32832921a7