In-Depth Study of Tripeptide-Based alpha -Ketoheterocycles as Inhibitors of Thrombin. Effective Utilization of the S sub(1)' Subsite and Its Implications to Structure-Based Drug Design

Thrombin inhibitors are potentially useful in medicine for their anticoagulant and antithrombotic effects. We synthesized and evaluated diverse heterocycle-activated ketones based on the D-Phe-Pro-Arg, and related thrombin active-site recognition motifs, as candidate inhibitors. The peptide-based al...

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Bibliographic Details

Published in:	Journal of medicinal chemistry Vol. 48; no. 6; pp. 1984 - 2008
Main Authors:	Costanzo, MJ, Almond, HR Jr, Hecker, L R, Schott, M R, Yabut, S C, Zhang, H-C, Andrade-Gordon, P, Corcoran, T W, Giardino, E C, Kauffman, JA, Lewis, J M, de Garavilla, L, Haertlein, B J, Maryanoff, B E
Format:	Journal Article
Language:	English
Published:	24-03-2005
Online Access:	Get full text
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