NK sub(1) antagonists based on seven membered lactam scaffolds

A new class of high affinity hNK sub(1)R antagonists based on seven-membered ring cores has been identified. This series, with relatively simple, compact structures, includes compounds with high affinity, good selectivity, and promising in vivo properties.

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Bibliographic Details
Published in:	Bioorganic & medicinal chemistry letters Vol. 16; no. 11; pp. 2929 - 2932
Main Authors:	Elliott, Jason M, Carlson, Emma J, Chicchi, Gary G, Dirat, Olivier, Dominguez, Maria, Gerhard, Ute, Jelley, Richard, Jones, ABrian, Kurtz, Marc M, Tsao, Kwei lan, Wheeldon, Alan
Format:	Journal Article
Language:	English
Published:	01-01-2006
Online Access:	Get full text
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Description
Summary:	A new class of high affinity hNK sub(1)R antagonists based on seven-membered ring cores has been identified. This series, with relatively simple, compact structures, includes compounds with high affinity, good selectivity, and promising in vivo properties.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 content type line 23 ObjectType-Feature-2
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2006.02.080