Differentiation of human embryonic stem cells to HOXA super(+) hemogenic vasculature that resembles the aorta-gonad-mesonephros

The ability to generate hematopoietic stem cells from human pluripotent cells would enable many biomedical applications. We find that hematopoietic CD34 super(+) cells in spin embryoid bodies derived from human embryonic stem cells (hESCs) lack HOXA expression compared with repopulation-competent hu...

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Bibliographic Details

Published in:	Nature biotechnology Vol. 34; no. 11; pp. 1168 - 1179
Main Authors:	Ng, Elizabeth S, Azzola, Lisa, Bruveris, Freya F, Calvanese, Vincenzo, Phipson, Belinda, Vlahos, Katerina, Hirst, Claire, Jokubaitis, Vanta J, Yu, Qing C, Maksimovic, Jovana, Liebscher, Simone, Januar, Vania, Zhang, Zhen, Williams, Brenda, Conscience, Aude, Durnall, Jennifer, Jackson, Steven, Costa, Magdaline, Elliott, David, Haylock, David N, Nilsson, Susan K, Saffery, Richard, Schenke-Layland, Katja, Oshlack, Alicia, Mikkola, Hanna K A, Stanley, Edouard G, Elefanty, Andrew G
Format:	Journal Article
Language:	English
Published:	01-11-2016
Online Access:	Get full text
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