CD8 super(+) T Cell Tolerance to a Tumor-associated Antigen Is Maintained at the Level of Expansion Rather than Effector Function

CD8 super(+) T cell tolerance to self-proteins prevents autoimmunity but represents an obstacle to generating T cell responses to tumor-associated antigens. We have made a T cell receptor (TCR) transgenic mouse specific for a tumor antigen and crossed TCR-TG mice to transgenic mice expressing the tu...

Full description

Bibliographic Details

Published in:	The Journal of experimental medicine Vol. 195; no. 11; pp. 1407 - 1418
Main Authors:	Oehlen, C, Kalos, M, Cheng, LE, Shur, A C, Hong, D J, Carson, B D, Kokot, NCT, Lerner, C G, Sather, B D, Huseby, E S, Greenberg, P D
Format:	Journal Article
Language:	English
Published:	01-06-2002
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!