Body Composition is Associated with Arterial Stiffness and Physical Function in Chronic Kidney Disease Patients

• Published in: Medicine and science in sports and exercise Vol. 44; no. 5S; p. 341
• Main Authors: Jeong, Jin H, Wu, Pei-Tzu, Tomayko, Emily J, Chung, Hae R, Kistler, Brandon M, Fitchen, Peter M, Fernhall, Bo, Wilund, Kenneth R
• Format: Journal Article
• Language: English
• Published: 01-05-2012
• ISSN: 0195-9131

PURPOSE: To determine the association of fat mass and lean mass with cardiovascular disease (CVD) risk factors and physical function in a cross-sectional analysis of patients undergoing maintenance hemodialysis. METHODS: Sixty-five hemodialysis patients were recruited (men=41, women=24; 54.2+ or -11.8). Whole body lean mass (LM) and fat mass (FM) were measured using dual-energy X-ray absorptiometry (DXA). RESULTS: Among 65 subjects, AIx was significantly correlated with BMI (r=-.25, p<.05); however, this was primarily due to a correlation between AIx and LM (r=-.34, p<.01), while there was no correlation between AIx and FM. AIx decreased 3% for each 10g increase of LM (F(2, 62)=5.1; p<.01). Percent body fat was associated with worse performance on several metrics of physical function, including gait speed, shuttle walk distance, time on 8-foot up-and-go, and repetitions of chair-stand (r=.32, -.45, .34, and -.36 respectively; p<.05).