Muscle Protein Metabolism In Neonatal Alloxan-administered Rats: Effects Of Resistance Training

• Published in: Medicine and science in sports and exercise Vol. 44; no. 5S; p. 449
• Main Authors: Ribeiro, Carla, Cambri, Lucieli Teresa, Voltarelli, Fabricio de Azevedo, Dalia, Rodrigo Augusto, de Araujo, Michel Barbosa, Botezelli, Jose Diego, de Moura, Leandro Pereira, de Mello, Maria Alice Rostom
• Format: Journal Article
• Language: English
• Published: 01-05-2012
• ISSN: 0195-9131

PURPOSE: Thus, this study aimed to examine the effects of resistance training on muscle protein metabolism in neonatal alloxan-administered rats. METHODS: Alloxan was injected in newborn rats at 6 days of age (250 mg/kg bw). At 28 days of age, the animals were divided into sedentary alloxan (SA), sedentary control (SC), resistance trained alloxan (TA), resistance trained control (TC) groups. RESULTS: The AUC was higher in the SA and TA when compared to corresponding controls SC and TC (SA=14140 + or - 672 > SC=13064 + or -683 TA=15234+ or - 657 > TC=14085 + or - 392). No differences in protein synthesis (SC=12.77+ or - 5.76 SA= 11.06 + or -2.21 TC=15.32 + or -2.73 TA=16.48+ or - 3.03) and protein degradation (SC=287.93+ or - 37.38 SA=350.56+ or - 90.71 TC= 281.26 + or -127.88 TA= 305.11+ or - 124.13) in the soleus muscle among the groups were observed.