Inhibition of DNA Synthesis by a Farnesyltransferase Inhibitor Involves Inhibition of the p70 super(s6k) Pathway

Previously, the protein farnesyltransferase inhibitor (FTI), L-744,832, has been shown to inhibit the proliferation of a number of tumor cell lines in vitro in a manner that correlated with the inhibition of the mitogen- activated protein kinase cascade. Here we show that FTI inhibits p70 super(s6k)...

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Bibliographic Details

Published in:	The Journal of biological chemistry Vol. 274; no. 8; pp. 4743 - 4748
Main Authors:	Law, B K, Noergaard, P, Gnudi, L, Kahn, B B, Poulson, H S, Moses, H L
Format:	Journal Article
Language:	English
Published:	19-02-1999
Online Access:	Get full text
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