Association of common eNOS/NOS sub(3) polymorphisms with preeclampsia in Tunisian Arabs

• Published in: Gene Vol. 569; no. 2; pp. 303 - 307
• Main Authors: Ben Ali Gannoun, Marwa, Zitouni, Hedia, Raguema, Nozha, Maleh, Wided, Gris, Jean-Christophe, Almawi, Wassim, Mahjoub, Touhami
• Format: Journal Article
• Language: English
• Published: 01-09-2015
• ISSN: 0378-1119
• DOI: 10.1016/j.gene.2015.05.072

We investigated the association of endothelial nitric oxide synthase (NOS sub(3)) polymorphisms -786T>C, 27-bp repeat 4b/4a, and Glu298Asp with preeclampsia (PE). This was a case-control study involving 345 unrelated Tunisian women with PE and 289 unrelated age- and ethnically matched control women. The -786C allele was significantly increased in PA patients when compared to healthy controls (P =0.015). In contrast, MAF of Glu298Asp (P =0.103) and 4b/4a (P =0.168) were not significantly different between the study groups. Higher frequencies of heterozygous Glu298/298Asp and homozygous -786T/-786T genotypes were seen in PE cases compared to healthy subjects. The combination of genotypes 221 (-786T>C, Glu298Asp, 4a/4a) was more in PE cases compared with control women (17.68% vs. 8.36%; P =0.029). Multivariate regression analysis confirmed this association. Genetic variation at the NOS sub(3) locus represents a genetic risk factor for increased susceptibility to PE.