Evidence for involvement of multiple forms of cytochrome P-450 in aflatoxin B sub(1) metabolism in human liver

Liver cancer is a major cause of premature death in many areas of Africa and Asia and its incidence is strongly correlated with exposure to aflatoxin B sub(1) (AFB sub(1)). Because AFB sub(1) requires metabolic activation to achieve a biological response, there is a need for detailed knowledge of th...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 87; no. 21; pp. 8306 - 8310
Main Authors:	rester, L M, Neal, GE, Judah, D J, Glancey, MJ, Wolf, C R
Format:	Journal Article
Language:	English
Published:	01-01-1990
Subjects:	aflatoxin B1 cytochrome P450
Online Access:	Get full text
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Summary:	Liver cancer is a major cause of premature death in many areas of Africa and Asia and its incidence is strongly correlated with exposure to aflatoxin B sub(1) (AFB sub(1)). Because AFB sub(1) requires metabolic activation to achieve a biological response, there is a need for detailed knowledge of the mechanism of activation to assess individual risk. We have carried out an extensive study using a total of 19 human liver samples to determine the individual variability in the metabolism of the toxin to mutagenic or detoxification products and to identify the specific cytochrome P-450 forms involved in these processes.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 content type line 23 ObjectType-Feature-2
ISSN:	0027-8424