Angiotensin-converting enzyme inhibitors. 9. Novel ((N-(-carboxy-3-phenylpropyl)-amino)acyl)glycine derivatives with diuretic activity

A series of molecules 1 having sulfonamide diuretic moieties covalently linked to non-sulfhydryl angiotensin-converting enzyme inhibitors (ACEI) were prepared and tested for both activities. IC sub(50) values for ACEI as low as 7 nM were observed. Discernible diuretic activity was seen for several h...

Full description

Saved in:
Bibliographic Details
Published in:Journal of medicinal chemistry Vol. 33; no. 6; pp. 1600 - 1606
Main Authors: Barton, J N, Piwinski, J J, Skiles, J W, Regan, J R, Menard, PR, Desai, R, Golec, F S, Reilly, L W, Suhn, J T
Format: Journal Article
Language:English
Published: 01-01-1990
Subjects:
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A series of molecules 1 having sulfonamide diuretic moieties covalently linked to non-sulfhydryl angiotensin-converting enzyme inhibitors (ACEI) were prepared and tested for both activities. IC sub(50) values for ACEI as low as 7 nM were observed. Discernible diuretic activity was seen for several hydrochlorothiazide-based molecules. Effects of the ACEI and diuretic structures on the respective potencies are discussed.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
content type line 23
ObjectType-Feature-2
ISSN:0022-2623