Angiotensin-converting enzyme inhibitors. 9. Novel ((N-(-carboxy-3-phenylpropyl)-amino)acyl)glycine derivatives with diuretic activity
A series of molecules 1 having sulfonamide diuretic moieties covalently linked to non-sulfhydryl angiotensin-converting enzyme inhibitors (ACEI) were prepared and tested for both activities. IC sub(50) values for ACEI as low as 7 nM were observed. Discernible diuretic activity was seen for several h...
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Published in: | Journal of medicinal chemistry Vol. 33; no. 6; pp. 1600 - 1606 |
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Main Authors: | , , , , , , , , |
Format: | Journal Article |
Language: | English |
Published: |
01-01-1990
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Subjects: | |
Online Access: | Get full text |
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Summary: | A series of molecules 1 having sulfonamide diuretic moieties covalently linked to non-sulfhydryl angiotensin-converting enzyme inhibitors (ACEI) were prepared and tested for both activities. IC sub(50) values for ACEI as low as 7 nM were observed. Discernible diuretic activity was seen for several hydrochlorothiazide-based molecules. Effects of the ACEI and diuretic structures on the respective potencies are discussed. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 content type line 23 ObjectType-Feature-2 |
ISSN: | 0022-2623 |