TRIM3, a tumor suppressor linked to regulation of p21 super(Waf1/Cip1)

• Published in: Oncogene Vol. 33; no. 3; pp. 308 - 315
• Main Authors: Liu, Y, Raheja, R, Yeh, N, Ciznadija, D, Pedraza, A M, Ozawa, T, Hukkelhoven, E, Erdjument-Bromage, H, Tempst, P, Gauthier, N P, Brennan, C, Holland, E C, Koff, A
• Format: Journal Article
• Language: English
• Published: 16-01-2014
• ISSN: 0950-9232
• DOI: 10.1038/onc.2012.596

The TRIM family of genes is largely studied because of their roles in development, differentiation and host cell antiviral defenses; however, roles in cancer biology are emerging. Loss of heterozygosity of the TRIM3 locus in similar to 20% of human glioblastomas raised the possibility that this NHL-domain containing member of the TRIM gene family might be a mammalian tumor suppressor. Consistent with this, reducing TRIM3 expression increased the incidence of and accelerated the development of platelet-derived growth factor -induced glioma in mice. Furthermore, TRIM3 can bind to the cdk inhibitor p21 super(WAF1/CIP1). Thus, we conclude that TRIM3 is a tumor suppressor mapping to chromosome 11p15.5 and that it might block tumor growth by sequestering p21 and preventing it from facilitating the accumulation of cyclin D1-cdk4.