Induction of benzo(a)pyrene mono-oxygenase in fish and the Salmonella test as a tool for mutagenic/carcinogenic xenobiotics in the aquatic environment
In order to study the induction of benzo(a)pyrene mono-oxygenase (BPHO) as a means of detoxification in fish, the authors used aliquots of extracts of polluted water in Salmonella/microsome mutagenicity tests with liver homogenates of pollution induced fish as activating systems. A single injection...
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| Published in: | Bulletin of environmental contamination and toxicology Vol. 21; no. 6; pp. 799 - 807 |
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| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
01-01-1979
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| Online Access: | Get full text |
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| Summary: | In order to study the induction of benzo(a)pyrene mono-oxygenase (BPHO) as a means of detoxification in fish, the authors used aliquots of extracts of polluted water in Salmonella/microsome mutagenicity tests with liver homogenates of pollution induced fish as activating systems. A single injection of an appropriate substance can induce BPMO activity in carp within one or two days. Mugil cephalus caught in a mixing zone of a fish cannery outlet had a much higher BPMO activity than specimens caught in clean areas. The substances tested were only mutagenic in the presence of liver postmitochondrial fraction and that substances which require metabolic transformation to an active compound, produced revertants when the liver fraction from untreated carp was added. |
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| Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 content type line 23 ObjectType-Feature-1 |
| ISSN: | 0007-4861 |