Nonopioid effect of [beta]-endorphin

Nonopioid effect of [beta]-endorphin

This review presents the generalized literature data and the results of our own research of the nonopioid effect of β-endorphin, an opioid neuropeptide interacting not only with opioid but also with nonopioid (insensitive to the opioid antagonist naloxone) receptors. The roles of the hormone and its...

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Bibliographic Details
Published in:Biochemistry (Moscow) Vol. 76; no. 4; p. 379
Main Authors: Kovalitskaya, Yu A, Navolotskaya, E V
Format: Journal Article
Language:English
Published: New York Springer Nature B.V 01-04-2011
Subjects:
Endocrine system
Hormones
Immune system
Nervous system
Peptides
Pharmacology
Online Access:Get full text
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Summary:This review presents the generalized literature data and the results of our own research of the nonopioid effect of β-endorphin, an opioid neuropeptide interacting not only with opioid but also with nonopioid (insensitive to the opioid antagonist naloxone) receptors. The roles of the hormone and its receptors in regulation of the immune, nervous, and endocrine systems are discussed. The effect of neuromediator on the immune system mediated by both opioid and nonopioid receptors is considered in detail. The data on distribution and function of the nonopioid β-endorphin receptor in human and animal organisms are presented. All available data on the characteristics of the nonopioid β-endorphin receptor obtained by means of radioligand analysis are given. The discussed information is supposed to extend our conceptions of the role of β-endorphin in mammals and to be of extensive use in medicine and pharmacology.[PUBLICATION ABSTRACT]
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297911040018