Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1[alpha]-induced metabolic reprograming

As chronic myeloid leukemia (CML) progresses from the chronic phase to blast crisis, the levels of BCR-ABL increase. In addition, blast-transformed leukemic cells display enhanced resistance to imatinib in the absence of BCR-ABL-resistance mutations. In this study, we show that when BCR-ABL-transfor...

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Bibliographic Details

Published in:	Oncogene Vol. 29; no. 20; p. 2962
Main Authors:	Zhao, F, Mancuso, A, Bui, T V, Tong, X, Gruber, J J, Swider, C R, Sanchez, P V, Lum, J J, Sayed, N, Melo, J V, Perl, A E, Carroll, M, Tuttle, S W, Thompson, C B
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group 20-05-2010
Subjects:	Cellular biology Genetics Leukemia Metabolism Mutation
Online Access:	Get full text
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