Proprotein convertase 1 and 2 profiles in human liver colorectal metastases
The family of proprotein convertases has been recently implicated in tumorigenesis and metastasis in animal models. However, these studies have not yet been completely corroborated in human tumors. Here, we show that mRNA, protein expression, and protein cleavage profiles of proprotein convertases 1...
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| Format: | Dissertation |
| Language: | English |
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ProQuest Dissertations & Theses
01-01-2004
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| Online Access: | Get full text |
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| Summary: | The family of proprotein convertases has been recently implicated in tumorigenesis and metastasis in animal models. However, these studies have not yet been completely corroborated in human tumors. Here, we show that mRNA, protein expression, and protein cleavage profiles of proprotein convertases 1 and 2 are altered in liver colorectal metastasis, compared to unaffected and normal liver. Active PC1 is overexpressed in tumor, correlating with its mRNA profile. Moreover, the enhanced PC2 processing pattern in tumor correlates with the overexpression of its specific chaperone 7B2, which in turn may represent a target for early diagnosis and treatment. The increased PC2 maturation, as well as the overexpression and altered processing of PC1 may be either a cause or a consequence for the observed metastasic phenotype. Nevertheless, they may result in the alteration of the secretory pathway, which could therefore, modify the cellular microenvironment and thus favor tumor growth and/or metastasis. |
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| ISBN: | 061298754X 9780612987548 |