Development and Characterization of Modified Release Oral Preparations Containing Riboflavin

• Main Author: Buchholcz, Gyula
• Format: Dissertation
• Language: English
• Published: ProQuest Dissertations & Theses 01-01-2015
• Subjects: Aqueous solutions; Bioavailability; Cellulose; Dissolution; Drug dosages; Homogenization; Humidity; Lactose; Mathematical models; Pharmaceutical industry; Pharmaceutical sciences; Polymer chemistry; Polymers; Protective coatings; Sodium; Software; Solvents; Vitamin B
• ISBN: 9798381054095

The vitamins essential for living organisms are normally consumed in small amounts with the food. These organic materials facilitate the biochemical reactions that produce, among others, skin, bone and muscle. Once growth and development are completed, the vitamins remain essential nutrients for the healthy maintenance of the cells, tissues and organs; they also ensure the efficient use of the chemical energy provided by the food and promote the processing of the proteins, carbohydrates and fats required for respiration [1].Riboflavin (Fig. 1.), a sparingly water-soluble vitamin that is a component of the coenzymes flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) is important in the utilization of food and the interconversion of energy.riboflavin + ATP FMN + ADPFMN + ATP FAD + PPRiboflavin has no overt pharmacological effects following its oral or parenteral administration. FMN and FAD, the physiologically active forms of riboflavin, serve a vital metabolic role as coenzymes for a wide variety of respiratory flavoproteins, some of which contain metals (e.g. xanthine oxidase) [2]. A deficiency of vitamin B2is associated with eye and skin disorders.There are a number of preparations containing riboflavin on the market, e.g. effervescent tablets and instant granules. Modern therapy additionally requires a modified release dosage form since the riboflavin-containing drugs have poor oral bioavailability due to the narrow absorption window in the gastrointestinal tract.