Association between IL-17F rs763780 and IL-17RA rs4819554 gene polymorphisms and psoriasis in a Romanian cohort

• Published in: Human & veterinary medicine Vol. 15; no. 1; pp. 7 - 13
• Main Authors: Puşcaş, Alexandra D, Morar, Iulia I, Vesa, Ştefan C, Cătană, Andreea, Ilieş, Roxana F, Candrea, Elisabeta, Puşcaş, Cristian, Orasan, Remus I
• Format: Journal Article
• Language: English
• Published: Cluj-Napoca Bioflux SRL 01-06-2023
• Subjects: Alleles; Antigens; Arthritis; Body mass index; Cholesterol; Disease; Environmental factors; Gene frequency; Gene polymorphism; Genes; Genotype & phenotype; Immune response; Interleukin 17; Interleukin 23; Pathogenesis; Pharmacy; Polymorphism; Population genetics; Population studies; Psoriasis; Psoriasis vulgaris; Single-nucleotide polymorphism; Skin; Triglycerides; Romania
• EISSN: 2066-7663
• ISSN: 2066-7655

Background. Psoriasis is a sistemic infammatory disease that appears as a result of complex and multifactorial interactions between polygenic background and environmental factors. Understanding of the pathogenesis of psoriasis has evolved continuously and recent evidence supports the critical role of the IL-23/IL-17 axis. Studies have identifed more than 80 loci related to the risk of psoriasis. These loci encode for key factors generated by the immune response. Several studies, conducted in diferent populations, studied the associations between SNPs in the IL-17 family genes and risk for developing psoriasis. Material and methods: We performed a prospective case-control study that included 81 patients diagnosed with moderate-to-severe chronic plaque psoriasis and 69 healthy volunteers. The following data were collected from both groups: age, alcohol consumption, smoking habits, BMI and levels of total cholesterol and triglycerides. All the patients were genotyped for rs763780 in IL-17F gene and rs4819554 in IL-17RA gene. Results: Genotype frequencies of IL-17RA rs4819554 variants were almost similar in the patient and control groups. GG genotype in case of psoriasis patients and A allele carriers in control group register a slightly increase frequency in each situation. In the Romanian population, no signifcant diference was detected in patients diagnosed with moderate to severe psoriasis vulgaris in terms of rs4819554 variants as compared to the control group. In contrast, IL-17F rs763780 TT genotype showed signif-cant diferences between psoriasis patients and controls, being associated with an increased risk of psoriasis (p=0.008). The C allele frequency (in dominant model CC+TC vs TT) was more common in controls compared to psoriasis patients (42% vs 21%). The overall frequencies of TT, TC and CC genotype were 79%, 17.3% and 3.7% in psoriasis patients vs 58%, 26.1% and 15.9% in the controls. Conclusion: We report an association between TT genotype of rs763780 in IL-17F and the risk for psoriasis, and a possible protective role of C allele for psoriasis, in a Romanian population.