Transcutaneous Ultrasound Loading of Piezoelectric-Driven Hernia Repair Mesh for Soft Tissue Healing

• Main Author: Drapal, Victoria A
• Format: Dissertation
• Language: English
• Published: ProQuest Dissertations & Theses 01-01-2022
• Subjects: Bioengineering; Biomedical engineering
• ISBN: 9798837546662

Annually in the United States, over one million hernia repairs surgeries occur. A hernia is a painful medical impediment where a portion of soft tissue protrudes through a damaged section of abdominal wall. The only real treatment for hernias is to repair and strengthen the injured abdominal lining. Hernias have a high recurrence rate which leads to surgeons utilizing surgical mesh to help strength the repair and reduce the recurrence rate. However, the use of synthetic mesh in hernia repairs can lead to recurrence rates due to rips or tears along the tissue and biomaterial interface, which leads to additional patient discomfort and difficulties. The recurrence rate for the first-time open hernia repair is 24% even with the use of a hernia repair mesh.1 Any patient can develop a hernia in their lifetime no matter age, physical condition, or demographic however, certain risk factors can increase a patient’s chances of a hernia occurrence such as obesity, tobacco use, and heavy lifting. Electrical stimulation (ES) for soft tissue repair and regeneration has shown promise in low voltage applications. However, for internal soft tissue regeneration, battery packs would be cumbersome and may require additional surgeries for removal. Low voltage can be made possible through piezoelectric discs that have the unique property of producing current through mechanical loading and thus does not need a battery pack. Therefore, a method of using ES as a conduit for soft tissue regeneration has been proposed. This novel biomedical product concept and the resulting viability will be explored in this thesis work. The piezoelectric-driven hernia repair mesh was assessed through biocompatibility and viability outcomes. Here, the hernia repair mesh was turned into an electrode through applying a thin layer of gold by sputter coating. The voltage source was a piezoelectric element that was activated through transcutaneous ultrasound loading to provide better healing prospects. The results from this study show viability of NIH 3T3 cells in vitro after 5-, 7-, and 14-days of stimulation. Overall viability results showed promise for the product concept after 5- and 7-days of stimulation. An unexpected complication in the electrode arose in the 14-day stimulation group. Limitations of the work and future work is discussed.