DEVELOPMENT AND EVALUATION OF THE EFFICIENCY OF AN ADAPTIVE SYSTEM FOR CONTROL TRANSMEMBRANE PRESSURE WEARABLE ARTIFICIAL KIDNEY

• Published in: International journal of artificial organs Vol. 42; no. 8
• Main Authors: Kolesnik, A Kolesnik, Bazaev, N A, Streltsov, E V
• Format: Journal Article
• Language: English
• Published: Milan Wichtig Editore s.r.l 01-08-2019
• Subjects: Accuracy; Adaptive control; Clamping; D C motors; Dialysis; Differential pressure; Differential thermal analysis; Electric motors; Flow velocity; Fluid flow; Kidneys; Motor task performance; Peristaltic pumps; Position measurement; Position sensing; Pressure; Pressure measurement; Pressure sensors; Primary circuits; Regeneration; Sensors; Solute movement; Three dimensional printing; Wearable technology
• ISSN: 0391-3988; 1724-6040

Solute movement from blood to dialysis solution is largely determined by transmembrane pressure (TMP). Accordingly, it was imperative to develop a TMP control system that allows for the maintanence of constant pressure. TMP in dialyzer is one of the tasks in wearable artificial kidney development. In most of the known devices, transmembrane pressure is regulated only by adjusting the flow–pressure characteristics of the pump or mechanical uncontrolled clamping line. A system was proposed which consists of a pinch valve, a DC motor and a control circuit. This device allows you to automatically adjust the pressure. At first, the device reads data from the differential sensor, which measures the TMP. After that, the position of the moving part of the pinch valve changes and the degree of сlamping of the line changes, which in turn affects the value of TMP. The case of the device was made using a 3D printer. A test bench was created in order to determine the effectiveness of maintaining a constant TMP. It consists of five parts: two circuits with two peristaltic pumps, a dialyzer, a differential pressure sensor and a power source. The pressure from the primary circuit was varied by manually clamping the line and the degree of pressure differential compensation by the pinch valve was determined. The experiment showed that the TMP changes are fully compensated by the pinch valve. Accuracy of the developed device depends largely on accuracy of pressure measurement sensor. There was no change in the flow rate of the fluid, and this is important, because the rate of dialysate regeneration depends on the flow rate of the fluid. The experiment showed that this device can be used to control TMP. Accuracy of the system allows you to use it in the wearable artificial kidney.