Upregulation of Bcl-x and Bfl-1 as a potential mechanism of chemoresistance, which can be overcome by NF-[kappa]B inhibition

In A549 human lung adenocarcinoma cells, we found that TNF-alpha and several commonly used chemotherapeutic agents upregulated the expression of Bcl-x and/or Bfl-1/A1 through an NF-kappaB-dependent pathway. While parental A549 cells were resistant to the cytotoxic effects of both TNF-alpha and chemo...

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Bibliographic Details

Published in:	Oncogene Vol. 19; no. 42; p. 4936
Main Authors:	Cheng, Qingwen, Lee, Ho H, Li, Ying, Parks, Thomas P, Cheng, Genhong
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group 05-10-2000
Online Access:	Get full text
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