Some mutations of exon-7 in cytochrome P450 gene 3A4 and their effect on 6[beta]-hydroxylation of cortisol

Some mutations of exon-7 in cytochrome P450 gene 3A4 and their effect on 6[beta]-hydroxylation of cortisol

Analysis of variants of exon 7 sequences in cytochrome P450 gene 3A4 in a sample of Caucasoid persons was carried out. The effect of these variants on activity of CYP3A was assessed by the level of cortisol 6β-hydroxylation. Alleles CYP3A4*5 and *17 were not detected: probably, these mutations are r...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine Vol. 141; no. 6; p. 701
Main Authors: Shchepotina, E G, Vavilin, V A, Goreva, O B, Lyakhovich, V V
Format: Journal Article
Language:English
Published: New York Springer Nature B.V 01-06-2006
Online Access:Get full text
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Summary:Analysis of variants of exon 7 sequences in cytochrome P450 gene 3A4 in a sample of Caucasoid persons was carried out. The effect of these variants on activity of CYP3A was assessed by the level of cortisol 6β-hydroxylation. Alleles CYP3A4*5 and *17 were not detected: probably, these mutations are rare and consequently they have little effect on the character of polymorphic distribution of CYP3A4 activity in this population. The incidence of CYP3A4*2 was 5.26%. The 6βOH-cortisol/cortisol ratio in an individual with CYP3A4*2/*2 genotype was 7.408, which corresponded to "slow metabolizer" phenotype in this sample.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-006-0257-2