Autoantibodies against glutamate, [gamma]-aminobutyric acid, and norepinephrine in mechanisms of neuropathic pain syndrome

• Published in: Bulletin of experimental biology and medicine Vol. 145; no. 5; p. 584
• Main Authors: Evseev, V A, Vetrile, L A, Smirnova, V S, Grafova, V N, Zaharova, I A, Trekova, N A, Kukushkin, M L
• Format: Journal Article
• Language: English
• Published: New York Springer Nature B.V 01-05-2008
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-008-0141-3

The production and role of autoantibodies against neurotransmitters glutamate, γ-aminobutyric acid, and norepinephrine were studied in rats with experimental neuropathic pain syndrome induced by sciatic nerve transection. Nerve transection in rats was followed by behavioral reaction of autotomy (self-mutilation of the operated limb), which often accompanies neuropathic pain syndrome. The development of neuropathic pain syndrome was accompanied by increased production of autoantibodies against glutamate, γ-aminobutyric acid, and norepinephrine. A negative correlation was found between the amount of autoantibodies against neurotransmitters and severity of neuropathic pain syndrome. Our results suggest that antibodies against glutamate and norepinephrine exhibit protective activity. [PUBLICATION ABSTRACT]