Incidental findings of 94 consecutive patients with psoriasis detected by FDG PET-MRI and PET-CT

• Published in: The Journal of nuclear medicine (1978) Vol. 58; p. 1234
• Main Authors: Civelek, Ali, Rana, Anshuma, Malayeri, Ashkan, Rodante, Justin, Dey, Amit, Bluemke, David, Mehta, Nehal
• Format: Journal Article
• Language: English
• Published: New York Society of Nuclear Medicine 01-05-2017
• Subjects: Diagnostic systems; Fatty liver; Fluorine isotopes; Liver; Lung nodules; Lymph nodes; Magnetic resonance imaging; Medical imaging; NMR; Nodules; Nuclear magnetic resonance; Nuclear medicine; Patients; Positron emission; Positron emission tomography; Psoriasis; Skin; Steatosis; Tables; Tomography
• ISSN: 0161-5505; 1535-5667

Objectives: To determine the type and frequency of incidental findings detected by 18F-FDG PET-MRI and 18F-FDG PET-CT in patients with psoriasis enrolled in a prospective cohort study. Methods: As part of a natural history study, patients with psoriasis undergo 18F-FDG PET-MRI (mean uptake time 136 minutes) and PET-CT (mean uptake time 60 min) on the same day.We evaluated 94 consecutive patients enrolled in the past 36 months to characterize incidental findings beyond dermal structures. Findings deemed to be non-consequential incidental are not included, such as benign calcified lymph nodes. All 188 18F-FDG PET scans, (94 PET-MRI and 94 PET-CT, of the 94 patients) were evaluated by the same physician. Results: The mean age of predominantly male sample was 49.9 (± 14.2 years) with mild to moderate psoriasis for an average of 20 years (Table-1). Table-2 demonstrates that the most frequent incidental findings on PET-MRI were gynecologic, renal, hepatic steatosis followed by lung nodules which were not FDG avid. The most frequent findings detected by FDG PET-CT were lung nodules. TABLE 1: Characteristics of the cohort. Conclusion: 18F-FDG PET-MRI has the potential to enhance the diagnostic power of the PET by augmenting anatomic resolution and soft-tissue contrast. In our preliminary analysis of patients with psoriasis, we demonstrate a high frequency of incidental findings detected by PET-MRI and PET-CT. The most common findings were renal, liver, gynecologic/pelvic, and indeterminate lung nodules. Research Support: (NCT: 01778569) and Siemens: Non-Financial Research Support