17[beta]-Estradiol Potentiates the Reinstatement of Cocaine Seeking in Female Rats: Role of the Prelimbic Prefrontal Cortex and Cannabinoid Type-1 Receptors

Clinical observations imply that female cocaine addicts experience enhanced relapse vulnerability compared with males, an effect tied to elevated estrogen phases of the ovarian hormone cycle. Although estrogens can enhance drug-seeking behavior, they do not directly induce reinstatement on their own...

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Bibliographic Details
Published in:	Neuropsychopharmacology (New York, N.Y.) Vol. 43; no. 4; p. 781
Main Authors:	Doncheck, Elizabeth M, Urbanik, Luke A, Debaker, Margot C, Barron, Laura M, Liddiard, Gage T, Tuscher, Jennifer J, Frick, Karyn M, Hillard, Cecilia J, Mantsch, John R
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group 01-03-2018
Subjects:	17β-Estradiol Activation Addicts Cannabinoids Cocaine Drug abuse Drug addiction Drug dosages Drug self-administration Estrogens Estrus cycle Extinction Extinction behavior Males Menopause Model testing Narcotics Ovariectomy Prefrontal cortex Pretreatment Rats Reinstatement Rodents Sex hormones
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