Different epigenetic mechanisms of ERa implicated in the fate of fulvestrant-resistant breast cancer

Approximately 70% of breast cancers express estrogen receptor α (ERα), which plays critical roles in breast cancer development. Fulvestrant has been effectively used to treat ERα-positive breast cancer, although resistance remains a critical problem. To elucidate the mechanism of resistance to fulve...

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Bibliographic Details
Published in:	The Journal of steroid biochemistry and molecular biology Vol. 167; p. 115
Main Authors:	Tsuboi, Kouki, Kaneko, Yosuke, Nagatomo, Takamasa, Fujii, Rika, Hanamura, Toru, Gohno, Tatsuyuki, Yamaguchi, Yuri, Niwa, Toshifumi, Hayashi, Shin-ichi
Format:	Journal Article
Language:	English
Published:	Oxford Elsevier BV 01-03-2017
Subjects:	AKT protein Breast cancer Cell growth Deoxyribonucleic acid DNA DNA methylation Estrogen receptors Estrogens Fulvestrant Gene expression Gene regulation MAP kinase Phosphorylation Plasticity Tumor cell lines Tumors
Online Access:	Get full text
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