C26 ASTHMA IN INFANTS AND CHILDREN: Neutrophil Elastase Restores Muscarinic 3 Receptor (m3r) Expression That Has Been Suppressed By Interleukin (il)-13

C26 ASTHMA IN INFANTS AND CHILDREN: Neutrophil Elastase Restores Muscarinic 3 Receptor (m3r) Expression That Has Been Suppressed By Interleukin (il)-13

Corresponding author's email: bruce.rubin@vcuhealth.org Rationale: Mucus secretion is increased in patients with asthma, and goblet cell hyperplasia is driven by IL-13 and neutrophil elastase (NE). Results: IL-13 decreased M3R mRNA expression (1.01±0.05 in control vs 0.47±0.05 at 5 ng/mL of IL-...

Full description

Saved in:
Bibliographic Details
Published in:American journal of respiratory and critical care medicine Vol. 195
Main Authors: Komiya, K, Akaba, T, Kozaki, Y, Rubin, B K
Format: Journal Article
Language:English
Published: New York American Thoracic Society 01-01-2017
Subjects:
Asthma
Neutrophils
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Corresponding author's email: bruce.rubin@vcuhealth.org Rationale: Mucus secretion is increased in patients with asthma, and goblet cell hyperplasia is driven by IL-13 and neutrophil elastase (NE). Results: IL-13 decreased M3R mRNA expression (1.01±0.05 in control vs 0.47±0.05 at 5 ng/mL of IL-13, p<0.001) and protein level (p<0.001) in a dose dependent manner, while NE increased M3R mRNA expression compare to control (p=0.002).
ISSN:1073-449X
1535-4970