Low serum FT4 and cortisol concentrations in early onset hyperphagic obesity: a clue to SIM1 deficiency

Low serum FT4 and cortisol concentrations in early onset hyperphagic obesity: a clue to SIM1 deficiency

Het psychomotor development was delayed and behavioral problems increased with age. Because of learning difficulties, she received special education type 8. Previous hormonal and metabolic investigations had shown a partial urinary concentration deficit during a water deprivation test, a low FT4 wit...

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Bibliographic Details
Published in:Acta clinica belgica (English ed. Online) Vol. 71; no. S2; p. 11
Main Authors: Zeevaert, R, Gies, I, Vanbesien, J, De Schepper, J
Format: Journal Article
Language:English
Published: Ghent Taylor & Francis Ltd 01-03-2016
Subjects:
Age
Hormones
Laboratories
Learning disabilities
Obesity
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Summary:Het psychomotor development was delayed and behavioral problems increased with age. Because of learning difficulties, she received special education type 8. Previous hormonal and metabolic investigations had shown a partial urinary concentration deficit during a water deprivation test, a low FT4 with normal TSH concentration, an elevated leptin concentration for age, but normal for degree of obesity, and insulin resistance on OGTT Genetic studies included a normal karyotype and a negative screening for Prader-Willi syndrome (PWS) and for MRC4 gene mutation.
ISSN:1784-3286
2295-3337