Severe Paradoxical Reaction During Treatment of Disseminated Tuberculosis in a Patient With Neutralizing Anti-IFN[Gamma] Autoantibodies

Interferon-gamma (IFNy) neutralizing autoantibodies are associated with disseminated nontuberculous mycobacterial infections. We report a previously healthy Thai woman with disseminated tuberculosis and high-titer IFNy-neutralizing autoantibodies, who developed a severe inflammatory reaction during...

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Bibliographic Details
Published in:	Clinical infectious diseases Vol. 62; no. 6; p. 770
Main Authors:	Xie, Yingda L, Rosen, Lindsey B, Sereti, Irini, Barber, Daniel L, Chen, Ray Y, Hsu, Denise C, Qasba, S Sonia, Zerbe, Christa S, Holland, Steven M, Browne, Sarah K
Format:	Journal Article
Language:	English
Published:	Oxford Oxford University Press 15-03-2016
Subjects:	Bacteria Bacterial infections Immunoglobulins Medical treatment Tuberculosis
Online Access:	Get full text
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Summary:	Interferon-gamma (IFNy) neutralizing autoantibodies are associated with disseminated nontuberculous mycobacterial infections. We report a previously healthy Thai woman with disseminated tuberculosis and high-titer IFNy-neutralizing autoantibodies, who developed a severe inflammatory reaction during anti-tuberculosis treatment. IFNy contributes to host control of tuberculosis but appears inessential for tuberculosis paradoxical reactions.
ISSN:	1058-4838 1537-6591