Pentoxifylline Reverses Chronic Experimental Chagasic Cardiomyopathy in Association with Repositioning of Abnormal CD8 + T-Cell Response e0003659

Background Chronic chagasic cardiomyopathy (CCC), the main clinical sign of Chagas disease, is associated with systemic CD8+ T-cell abnormalities and CD8-enriched myocarditis occurring in an inflammatory milieu. Pentoxifylline (PTX), a phosphodiesterase inhibitor, has immunoregulatory and cardioprot...

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Bibliographic Details

Published in:	PLoS neglected tropical diseases Vol. 9; no. 3
Main Authors:	Pereira, Isabela Resende, Vilar-Pereira, Glaucia, Moreira, Otacilio Cruz, Ramos, Isalira Peroba, Gibaldi, Daniel, Britto, Constança, Moraes, Milton Ozório, Lannes-Vieira, Joseli
Format:	Journal Article
Language:	English
Published:	San Francisco Public Library of Science 01-03-2015
Subjects:	Cardiomyopathy Cardiovascular disease Experiments Heart failure Immunology Infections Interferon Parasites Parasitic diseases Pathogenesis Protozoa Spleen Tropical diseases
Online Access:	Get full text
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