A Common Synthetic Protocol for the Cyclic and Acyclic Core of Migrastatin, Isomigrastatin, and Dorrigocin via a Chiral [beta]-Hydroxy-[gamma]-butyrolactone Intermediate
A facile synthetic route has been developed for the synthesis of the cyclic and acyclic cores of migrastatin, isomigrastatin, and dorrigocin. The common synthetic route goes via a [beta]-hydroxy-[gamma]-butyrolactone intermediate that is obtained by a PdII-catalysed asymmetric allylic intramolecular...
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| Published in: | European journal of organic chemistry Vol. 2014; no. 29; p. 6558 |
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| Main Authors: | , |
| Format: | Journal Article |
| Language: | English |
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Weinheim
Wiley Subscription Services, Inc
01-10-2014
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| Abstract | A facile synthetic route has been developed for the synthesis of the cyclic and acyclic cores of migrastatin, isomigrastatin, and dorrigocin. The common synthetic route goes via a [beta]-hydroxy-[gamma]-butyrolactone intermediate that is obtained by a PdII-catalysed asymmetric allylic intramolecular cyclization of 3-hydroxy-2-methylhex-5-enoic acid following a protocol developed by White and coworkers. |
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| AbstractList | A facile synthetic route has been developed for the synthesis of the cyclic and acyclic cores of migrastatin, isomigrastatin, and dorrigocin. The common synthetic route goes via a [beta]-hydroxy-[gamma]-butyrolactone intermediate that is obtained by a PdII-catalysed asymmetric allylic intramolecular cyclization of 3-hydroxy-2-methylhex-5-enoic acid following a protocol developed by White and coworkers. |
| Author | Gade, Narendar Reddy Iqbal, Javed |
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| ContentType | Journal Article |
| Copyright | Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim |
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| DOI | 10.1002/ejoc.201402830 |
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| Title | A Common Synthetic Protocol for the Cyclic and Acyclic Core of Migrastatin, Isomigrastatin, and Dorrigocin via a Chiral [beta]-Hydroxy-[gamma]-butyrolactone Intermediate |
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