Glutathione S-transferase M1 modulates allergen-induced NF-[kappa]B activation in asthmatic airway epithelium

Background Glutathione S-transferase M1 (GSTM1) is a phase II enzyme and regulator of inflammatory signaling in airway epithelial cells. We have found upregulation of neutrophilic airway inflammation in atopic asthmatics expressing GSTM1 gene (GSTM1+) compared to GSTM1null asthmatics. We hypothesize...

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Bibliographic Details
Published in:	Allergy (Copenhagen) Vol. 69; no. 12; p. 1666
Main Authors:	Polosukhin, V V, Polosukhin, I V, Hoskins, A, Han, W, Abdolrasulnia, R, Blackwell, T S, Dworski, R
Format:	Journal Article
Language:	English
Published:	Zurich Blackwell Publishing Ltd 01-12-2014
Subjects:	Allergies Asthma Enzymes Polymorphism
Online Access:	Get full text
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