Impaired production of TNF-[alpha] by dendritic cells of older adults leads to a lower CD8+ T cell response against influenza

Impaired production of TNF-[alpha] by dendritic cells of older adults leads to a lower CD8+ T cell response against influenza

Highlights * We investigate DCs of healthy older (>=65years) and young adults (20-40years). * DCs of older adults show an impaired activation of influenza-specific CD8+ T cells. * Mature DCs of older adults express less TNF-α, HLA class I and maturation markers. * Supplementing TNF-α restores DC...

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Bibliographic Details
Published in:Vaccine Vol. 30; no. 9; p. 1659
Main Authors: Liu, Wai Ming, Nahar, Thamar ER, Jacobi, Ronald HJ, Gijzen, Karlijn, van Beek, Josine, Hak, Eelko, Jonges, Marcel, Boog, Claire JP, van der Zeijst, Bernard AM, Soethout, Ernst C
Format: Journal Article
Language:English
Published: Kidlington Elsevier Limited 21-02-2012
Subjects:
Antigens
Cytokines
Immune system
Influenza
Older people
T cell receptors
Vaccines
Young adults
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Summary:Highlights * We investigate DCs of healthy older (>=65years) and young adults (20-40years). * DCs of older adults show an impaired activation of influenza-specific CD8+ T cells. * Mature DCs of older adults express less TNF-α, HLA class I and maturation markers. * Supplementing TNF-α restores DC function of older adults. * TNF-α is a major factor in the DC-mediated CD8+ T cell response against influenza.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2011.12.105