12- to 22-Membered Bridged [beta]-Lactams as Potential Penicillin-Binding Protein Inhibitors

As potential inhibitors of penicillin-binding proteins (PBPs), we focused our research on the synthesis of non-traditional 1,3-bridged [beta]-lactams embedded into macrocycles. We synthesized 12- to 22-membered bicyclic [beta]-lactams by the ring-closing metathesis (RCM) of bis-[omega]-alkenyl-3(S)-...

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Bibliographic Details

Published in:	Chemistry, an Asian journal Vol. 7; no. 2; p. 425
Main Authors:	Sliwa, Aline, Dive, Georges, Marchand-Brynaert, Jacqueline
Format:	Journal Article
Language:	English
Published:	Weinheim Wiley Subscription Services, Inc 01-02-2012
Subjects:	Bacteriology Chemistry Penicillin
Online Access:	Get full text
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