IL-12/TGF-[beta]1 Regulation of TCR Signal Transduction in Human Memory T Cells Associated with Malignant and Non-malignant Chronic Inflammatory Microenvironments

IL-12/TGF-[beta]1 Regulation of TCR Signal Transduction in Human Memory T Cells Associated with Malignant and Non-malignant Chronic Inflammatory Microenvironments

Effector memory T cells were isolated from the primary, human, non-small cell lung tumors, nasal polyps and synovial fluid of rheumatic joints and evaluated for their response to TCR stimulation via CD3+CD28 cross-linking by nuclear translocation of NF-κB and NFAT under confocal microscopy.

Saved in:
Bibliographic Details
Published in:Journal of allergy and clinical immunology Vol. 119; no. 1; p. S92
Main Authors: Broderick, L, Bankert, RB
Format: Journal Article
Language:English
Published: St. Louis Elsevier Limited 01-01-2007
Subjects:
Lymphocytes
Tumors
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Effector memory T cells were isolated from the primary, human, non-small cell lung tumors, nasal polyps and synovial fluid of rheumatic joints and evaluated for their response to TCR stimulation via CD3+CD28 cross-linking by nuclear translocation of NF-κB and NFAT under confocal microscopy.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2006.11.389